| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-12-12 |
| タイトル |
|
|
タイトル |
Digoxin induces inner ear damage |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
digoxin, ganglion cells, hair cells |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11877461 |
| 著者 |
Ogita, Hideaki
Taura, Akiko
Nishimura, Koji
Ohnishi, Hiroe
MIiwa, Toru
Miki, Shiho
Yamada, Yoshihiro
Ito, Juichi
|
| 抄録(英) |
|
|
内容記述 |
Auditory neuropathy is a hearing disorder in which the inner ear can detect sounds, but has a problem with sending sounds to the brain. The main pathology might be the disorder between inner hair cell synapse and cochlear nerve. Although it is an indication for cochlear implants, there is no radical treatment yet. Therefore, a neuropathy model using animals is needed for the development of new treatment. So, we investigated digoxin-induced inner ear disorders using guinea pigs. As the results , when the digoxin was administrated into the cochlea, the number of cochlear spiral ganglion cells decreased. However, no obvious damage was observed to the cochlear hair cells. As the result of ABR (Auditory Brainstem Response), physiological dysfunction was also confirmed. As for the effect on the vestibule, the vestibular ganglion cells were damaged, but the hair cells in the otoliths and in the ampulla were not damaged. These results suggest that digoxin might be useful drug for the generation of the animal model to auditory neuropathy. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 19,
号 1,
p. 15-20,
ページ数 6,
発行日 2022-08-31
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348-480X |
Digoxin induces inner ear damage (1.0 MB)
