{"created":"2023-05-15T12:17:07.449471+00:00","id":816,"links":{},"metadata":{"_buckets":{"deposit":"f302530e-1142-48c2-b581-c3068b05ca3e"},"_deposit":{"created_by":8,"id":"816","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"816"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000816","sets":["7:83"]},"author_link":["2880","2979","2882","2972","2975","2976","2881","2974","2878","2883","2978","2877","2973","2879","1093","2977"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"20","bibliographicPageStart":"15","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"AINO JOURNAL"},{"bibliographic_title":"AINO JOURNAL","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Auditory neuropathy is a hearing disorder in which the inner ear can detect sounds, but has a problem with sending sounds to the brain. The main pathology might be　the disorder between inner hair cell synapse and cochlear nerve. Although it is an indication for cochlear implants, there is no radical treatment yet. Therefore, a neuropathy model using animals is needed for the development of new treatment. So, we investigated digoxin-induced inner ear disorders using guinea pigs. As the results , when the digoxin was administrated into the cochlea, the number of cochlear spiral ganglion cells decreased.  However, no obvious damage was observed to the cochlear hair cells. As the result of ABR (Auditory Brainstem Response), physiological dysfunction was also confirmed. As for the effect on the vestibule, the vestibular ganglion cells were damaged, but the hair cells in the otoliths and in the ampulla were not damaged. These results suggest that digoxin might be useful drug for the generation of the animal model to auditory neuropathy.","subitem_description_type":"Other"}]},"item_3_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11877461","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-480X","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto "},{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto  /Department of Medical Engineering, Faculty of Health Science, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto /Department of Otolaryngology-Head and Neck Surgery, Teikyo University Hospital, Mizonokuchi"},{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto "},{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto /Department of Otolaryngology, Tazuke Kofukai, Medical Research Institute, Kitano Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Physical Therapy, Faculty of Health Science, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Physical Therapy, Faculty of Health Science, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Shiga Medical Center Research Institute, Shiga, Japan /Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OHGITA, Hideaki"}],"nameIdentifiers":[{"nameIdentifier":"2972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAURA, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"2973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIMURA, Koji"}],"nameIdentifiers":[{"nameIdentifier":"2974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHNISHI, Hiroe"}],"nameIdentifiers":[{"nameIdentifier":"2975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIWA, Toru"}],"nameIdentifiers":[{"nameIdentifier":"2976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIKI, Shiho"}],"nameIdentifiers":[{"nameIdentifier":"2977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"2978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ITO, Juichi"}],"nameIdentifiers":[{"nameIdentifier":"2979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHGITA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAURA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIMURA, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHNISHI, Hiroe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIWA, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIKI, Shiho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ITO, Juichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2883","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-12"}],"displaytype":"detail","filename":"③OHGITA et al.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Digoxin induces inner ear damage","url":"https://aino.repo.nii.ac.jp/record/816/files/③OHGITA et al.pdf"},"version_id":"104835fd-b1ce-4874-af72-a1ae06edca62"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"digoxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ganglion cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hair cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Digoxin induces inner ear damage","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Digoxin induces inner ear damage"},{"subitem_title":"Digoxin induces inner ear damage","subitem_title_language":"en"}]},"item_type_id":"3","owner":"8","path":["83"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-12"},"publish_date":"2022-12-12","publish_status":"0","recid":"816","relation_version_is_last":true,"title":["Digoxin induces inner ear damage"],"weko_creator_id":"8","weko_shared_id":8},"updated":"2023-05-15T12:25:46.566460+00:00"}