| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-03-27 |
| タイトル |
|
|
タイトル |
Patterns of outgrowth of regenerating axons through spinal cord lesion |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
spinal cord injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
axonal regeneration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone marrow stromal cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Schwann cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
olfactory ensheathing cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
iPS cell, Muse cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11877461 |
| ページ属性 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
P |
| 論文名よみ |
|
|
タイトル |
Patterns of outgrowth of regenerating axons through spinal cord lesion |
| 著者 |
KANEKIYO, Kenji
NAKANO, Norihiko
HOMMA, Tamami
YAMADA, Yoshihiro
IDE, Chizuka
|
| 著者所属(英) |
|
|
|
en |
|
|
Institute of Regeneration and Rehabilitation, Aino University |
| 著者所属(英) |
|
|
|
en |
|
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Institute of Regeneration and Rehabilitation, Aino University |
| 著者所属(英) |
|
|
|
en |
|
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Institute of Regeneration and Rehabilitation, Aino University |
| 著者所属(英) |
|
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|
en |
|
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Department of Physical Therapy, Aino University |
| 著者所属(英) |
|
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|
en |
|
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Institute of Regeneration and Rehabilitation, Aino University |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Lecture |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
We found that bone marrow stromal cells (BMSCs) do not survive for long enough to serve as a scaffold for regenerating axons after transplantation in the injured spinal cord of rats. However, axonal regeneration was facilitated, possibly by trophic factors secreted from transplanted BMSCs. Regenerating axons were not associated with astrocytes, but surrounded by Schwann cells (SCs), and embedded in collagen fibril matrices just as the axons of peripheral nerves. Experiments involving the transplantation of SCs themselves indicated that, besides exogenous SCs, intrinsic SCs infiltrated the lesion and formed myelin sheaths on regenerating axons in the same manner as described with BMSC transplantation. The transplantation of olfactory ensheathing cells (OECs) showed that OECs themselves enclosed regenerating axons in the same manner as SCs. No study has been carried out to address whether such Schwann-like cells were derived from transplanted OECs or intrinsic SCs. However, the possibility cannot be excluded that intrinsic SCs contributed to surround regenerating axons. Neural stem cells (NSCs) derived from iPS cells survived long-term, emanating numerous axons that extended over a long distance through the host spinal cord tissue. However, no myelination occurred on regenerating axons, and no behavioral improvement was observed. It would be difficult to manipulate iPS-derived NSCs to appropriately integrate them into the host spinal cord tissue. In this respect, iPS cells have crucial problems concerning whether they can be integrated appropriately into the host tissue. Muse cells (multilineage-differentiating stress-enduring cells) were separated as SSEA3-positive cells from BMSCs. Transplanted Muse cells survived long-term, but they were not as effective as non-Muse cells or BMSCs for the treatment of infarcted brains, suggesting that trophic factors from non-Muse cells and BMSCs are involved in those effects. These findings indicate that intrinsic SCs and trophic factors released from transplants may play important roles in nerve regeneration of the spinal cord. Differing from the generally believed pattern of regeneration, glial cells are not necessarily needed as the scaffolds for growing axons in the spinal cord. |
| 書誌情報 |
en : Aino journal
巻 13,
発行日 2015-03-31
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| 表示順 |
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内容記述タイプ |
Other |
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内容記述 |
13 |
| アクセション番号 |
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|
内容記述タイプ |
Other |
|
内容記述 |
KJ00010274779 |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348480X |
KJ00010274779.pdf (840.3 kB)
