{"created":"2023-05-15T12:16:45.533624+00:00","id":413,"links":{},"metadata":{"_buckets":{"deposit":"cf0f1a3a-4598-4241-8608-2ce29f9a65e3"},"_deposit":{"created_by":4,"id":"413","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"413"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000413","sets":["7:45"]},"author_link":["1265","1263","1262","1264","1261"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-31","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"13","bibliographic_titles":[{},{"bibliographic_title":"Aino journal","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"We found that bone marrow stromal cells (BMSCs) do not survive for long enough to serve as a scaffold for regenerating axons after transplantation in the injured spinal cord of rats. However, axonal regeneration was facilitated, possibly by trophic factors secreted from transplanted BMSCs. Regenerating axons were not associated with astrocytes, but surrounded by Schwann cells (SCs), and embedded in collagen fibril matrices just as the axons of peripheral nerves. Experiments involving the transplantation of SCs themselves indicated that, besides exogenous SCs, intrinsic SCs infiltrated the lesion and formed myelin sheaths on regenerating axons in the same manner as described with BMSC transplantation. The transplantation of olfactory ensheathing cells (OECs) showed that OECs themselves enclosed regenerating axons in the same manner as SCs. No study has been carried out to address whether such Schwann-like cells were derived from transplanted OECs or intrinsic SCs. However, the possibility cannot be excluded that intrinsic SCs contributed to surround regenerating axons. Neural stem cells (NSCs) derived from iPS cells survived long-term, emanating numerous axons that extended over a long distance through the host spinal cord tissue. However, no myelination occurred on regenerating axons, and no behavioral improvement was observed. It would be difficult to manipulate iPS-derived NSCs to appropriately integrate them into the host spinal cord tissue. In this respect, iPS cells have crucial problems concerning whether they can be integrated appropriately into the host tissue. Muse cells (multilineage-differentiating stress-enduring cells) were separated as SSEA3-positive cells from BMSCs. Transplanted Muse cells survived long-term, but they were not as effective as non-Muse cells or BMSCs for the treatment of infarcted brains, suggesting that trophic factors from non-Muse cells and BMSCs are involved in those effects. These findings indicate that intrinsic SCs and trophic factors released from transplants may play important roles in nerve regeneration of the spinal cord. Differing from the generally believed pattern of regeneration, glial cells are not necessarily needed as the scaffolds for growing axons in the spinal cord.","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"13","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00010274779","subitem_description_type":"Other"}]},"item_3_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Lecture","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11877461","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348480X","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Physical Therapy, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Patterns of outgrowth of regenerating axons through spinal cord lesion"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KANEKIYO, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKANO, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOMMA, Tamami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IDE, Chizuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1265","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-27"}],"displaytype":"detail","filename":"KJ00010274779.pdf","filesize":[{"value":"840.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010274779.pdf","url":"https://aino.repo.nii.ac.jp/record/413/files/KJ00010274779.pdf"},"version_id":"caea5685-0dbe-44b2-b0b0-46fe6a545f2c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spinal cord injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"axonal regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone marrow stromal cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Schwann cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"olfactory ensheathing cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"iPS cell, Muse cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Patterns of outgrowth of regenerating axons through spinal cord lesion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Patterns of outgrowth of regenerating axons through spinal cord lesion","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["45"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-27"},"publish_date":"2019-03-27","publish_status":"0","recid":"413","relation_version_is_last":true,"title":["Patterns of outgrowth of regenerating axons through spinal cord lesion"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-05-15T12:56:28.260499+00:00"}