| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-03-27 |
| タイトル |
|
|
タイトル |
Characterization of T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H level associated with presumptive and diagnosed progressive myelomalacia in dogs |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
CD4+/CD8+ ratio, dog, myelomalacia, pNF-H, spinal cord |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 雑誌書誌ID |
|
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11877461 |
| 著者 |
Tamura, Katsutoshi
Takemitsu, Hiroshi
Kunimi, Maki
Yasukawa, Momoko
Ide, Chizuka
Nakamura, Tatsuo
|
| 抄録(英) |
|
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内容記述 |
The aim of this study was to characterize the T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H (pNF-H) in dogs diagnosed with progressive myelomalacia (PM) and dogs with presumptive PM. A retrospective case series of six dogs with confirmed PM and 8 dogs with presumptive PM was in vesrigared, conducted and clinical signs, magnetic resonance imaging (MRI), the somatosensory evoked potential. and T lymphocyte phenotype in clinical records and pNF-H levels in the peripheral blood were evaluated. pNF-H levels were determined in both study dogs and healthy controls (beagles). PM was clinically diagnosed based on : (Berger et al. 2007) MRI of disc-associated spinal cord compression, (Boylan et al. 2009) clinical progression from initial paraparesis or paraplegia, to thoracic limb lower motor neuron paresis, to tetraplegia associated with cranial migration to the extent of cutaneous trunci reflex loss and analgesia, leading to death via respiratory paralysis, and (Ceron et al. 2005) histological examination. All PM dogs were paraplegic and had signs of lower motor neuron lesions. The CD4+/CD8+ ratio in 13 out of the 14 dogs (92.9%) was significantly higher than that in healthy controls (p<0.001). pNF-H was only detected in the peripheral blood of PM dogs. In some PM dogs, we did not observe signal hyperintensity on T2-weighted MRI. Our study results indicate that the detection of pNF-H and a high CD4+/CD8+ ratio in the peripheral blood may Facilitate earlier diagnosis of PM than is possible with MRI. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 12,
号 1,
p. 3-11,
ページ数 9,
発行日 2014-03-31
|
| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348480X |
KJ00010274299.pdf (696.6 kB)
