{"created":"2023-05-15T12:16:44.545481+00:00","id":393,"links":{},"metadata":{"_buckets":{"deposit":"d012b8a0-1382-470d-b7a4-f4be32f4cc82"},"_deposit":{"created_by":4,"id":"393","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"393"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000393","sets":["7:44"]},"author_link":["1209","1206","1208","1205","1210","1207"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-31","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Aino journal","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The aim of this study was to characterize the T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H (pNF-H) in dogs diagnosed with progressive myelomalacia (PM) and dogs with presumptive PM. A retrospective case series of six dogs with confirmed PM and 8 dogs with presumptive PM was in vesrigared, conducted and clinical signs, magnetic resonance imaging (MRI), the somatosensory evoked potential. and T lymphocyte phenotype in clinical records and pNF-H levels in the peripheral blood were evaluated. pNF-H levels were determined in both study dogs and healthy controls (beagles). PM was clinically diagnosed based on : (Berger et al. 2007) MRI of disc-associated spinal cord compression, (Boylan et al. 2009) clinical progression from initial paraparesis or paraplegia, to thoracic limb lower motor neuron paresis, to tetraplegia associated with cranial migration to the extent of cutaneous trunci reflex loss and analgesia, leading to death via respiratory paralysis, and (Ceron et al. 2005) histological examination. All PM dogs were paraplegic and had signs of lower motor neuron lesions. The CD4+/CD8+ ratio in 13 out of the 14 dogs (92.9%) was significantly higher than that in healthy controls (p<0.001). pNF-H was only detected in the peripheral blood of PM dogs. In some PM dogs, we did not observe signal hyperintensity on T2-weighted MRI. Our study results indicate that the detection of pNF-H and a high CD4+/CD8+ ratio in the peripheral blood may Facilitate earlier diagnosis of PM than is possible with MRI. ","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"3","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00010274299","subitem_description_type":"Other"}]},"item_3_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11877461","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348480X","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Aikouishida Animal Hospital, Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University"},{"subitem_text_language":"en","subitem_text_value":"Aikouishida Animal Hospital"},{"subitem_text_language":"en","subitem_text_value":"Aikouishida Animal Hospital"},{"subitem_text_language":"en","subitem_text_value":"Aikouishida Animal Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Occupational Therapy, Faculty of Health Science, Aino Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University "}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Characterization of T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H level associated with presumptive and diagnosed progressive myelomalacia in dogs "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAMURA, Katsutoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKEMITSU, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KUNIMI, Maki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YASUKAWA, Momoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IDE, Chizuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKAMURA, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1210","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-27"}],"displaytype":"detail","filename":"KJ00010274299.pdf","filesize":[{"value":"696.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010274299.pdf","url":"https://aino.repo.nii.ac.jp/record/393/files/KJ00010274299.pdf"},"version_id":"029a5565-3221-4d95-94bf-d502f89ac6da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD4+/CD8+ ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myelomalacia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pNF-H","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spinal cord","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H level associated with presumptive and diagnosed progressive myelomalacia in dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H level associated with presumptive and diagnosed progressive myelomalacia in dogs","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["44"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-27"},"publish_date":"2019-03-27","publish_status":"0","recid":"393","relation_version_is_last":true,"title":["Characterization of T lymphocyte phenotype and phosphorylated axonal neurofilament subunit H level associated with presumptive and diagnosed progressive myelomalacia in dogs"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-05-15T12:57:29.855610+00:00"}