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Gadolinium neutron capture therapy for malignant brain tumors
https://aino.repo.nii.ac.jp/records/330
https://aino.repo.nii.ac.jp/records/330bac1a95e-3f11-45a8-aa02-f8ec24de35bf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005223106.pdf (964.6 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2019-03-27 | |||||||||
| タイトル | ||||||||||
| タイトル | Gadolinium neutron capture therapy for malignant brain tumors | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | neutron capture therapy, gadolinium, malignant brain tumors | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11877461 | |||||||||
| 著者 |
Takagaki, Masao
× Takagaki, Masao
× HOSMANE, Narayan S.
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| 抄録(英) | ||||||||||
| 内容記述 | Tumoricidal effect on malignant brain tumor of gadolinium neutron capture reactions has been preliminary studied. In-vitro C6 37% survival dose (D_<37>) were obtained at 3.55×10^<12>n/cm^2 in 500ppm ^nGd medium, 1.40×10^<12>n/cm^2 in 2,500ppm ^nGd containing medium, and 6.80×10^<12>n/cm^2 in Gd-free medium. The relative killing effect of GdNCT against control study was 1.92 fold for 500ppm ^nGd(+) and 4.86 fold for 2,500ppm Gd(+). The significant survival prolongation of 9L brain tumor rat was observed by intra-venous injection of GdDTPA. Mean survival via GdNCT was 33.5±3.0 days, and that of control rats was 16.4±0.6 days. The optimal Gd concentration was estimated less than 1,000ppm ^<157>Gd for various reasons, since neutron fluence rapidly decrease in the deeply seated tumor due to high absorption of neutron by Gd atoms. The maximum contribution of γ rays on tumor absorbed dose was less than 50%. In a spherical tumor model in diameter of 3cm, approximately 25% of absorbed dose was transferred by γ rays and more that 50% of that by internal conversion electrons. The peri-tumoral dose distribution does not decrease sharply like BNCT. The 10% decrease level was estimated to be 2-3cm from the tumor margin. This blunt dose distribution might be effective to destroy the invading tumor cells in the peri-tumoral lesion manifesting as high density area in T^2-weighted MRI. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : AINO JOURNAL 巻 6, 号 1, p. 39-44, ページ数 6, 発行日 2008-03-31 |
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| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1348480X | |||||||||
