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Gadolinium neutron capture therapy for malignant brain tumors
https://aino.repo.nii.ac.jp/records/330
https://aino.repo.nii.ac.jp/records/330bac1a95e-3f11-45a8-aa02-f8ec24de35bf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005223106.pdf (964.6 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-27 | |||||
| タイトル | ||||||
| タイトル | Gadolinium neutron capture therapy for malignant brain tumors | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | neutron capture therapy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | gadolinium | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | malignant brain tumors | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11877461 | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P | |||||
| 論文名よみ | ||||||
| タイトル | Gadolinium neutron capture therapy for malignant brain tumors | |||||
| 著者 |
TAKAGAKI, Masao
× TAKAGAKI, Masao× HOSMANE, Narayan S. |
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| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nursing, Aino Gakuin College:Department of Chemistry and Biochemistry, Northern Illinois University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biochemistry, Northern Illinois University | |||||
| 記事種別(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Original article | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Tumoricidal effect on malignant brain tumor of gadolinium neutron capture reactions has been preliminary studied. In-vitro C6 37% survival dose (D_<37>) were obtained at 3.55×10^<12>n/cm^2 in 500ppm ^nGd medium, 1.40×10^<12>n/cm^2 in 2,500ppm ^nGd containing medium, and 6.80×10^<12>n/cm^2 in Gd-free medium. The relative killing effect of GdNCT against control study was 1.92 fold for 500ppm ^nGd(+) and 4.86 fold for 2,500ppm Gd(+). The significant survival prolongation of 9L brain tumor rat was observed by intra-venous injection of GdDTPA. Mean survival via GdNCT was 33.5±3.0 days, and that of control rats was 16.4±0.6 days. The optimal Gd concentration was estimated less than 1,000ppm ^<157>Gd for various reasons, since neutron fluence rapidly decrease in the deeply seated tumor due to high absorption of neutron by Gd atoms. The maximum contribution of γ rays on tumor absorbed dose was less than 50%. In a spherical tumor model in diameter of 3cm, approximately 25% of absorbed dose was transferred by γ rays and more that 50% of that by internal conversion electrons. The peri-tumoral dose distribution does not decrease sharply like BNCT. The 10% decrease level was estimated to be 2-3cm from the tumor margin. This blunt dose distribution might be effective to destroy the invading tumor cells in the peri-tumoral lesion manifesting as high density area in T^2-weighted MRI. | |||||
| 書誌情報 |
en : Aino journal 巻 6, 発行日 2008-03-31 |
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| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 7 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00005223106 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1348480X | |||||
