{"created":"2023-05-15T12:16:41.166808+00:00","id":330,"links":{},"metadata":{"_buckets":{"deposit":"ba7189a3-bb80-4b1b-8110-5b8bd679daa5"},"_deposit":{"created_by":4,"id":"330","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"330"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000330","sets":["7:38"]},"author_link":["2469","1099"],"control_number":"330","item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"6","bibliographicPageEnd":"44","bibliographicPageStart":"39","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"AINO JOURNAL","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Tumoricidal effect on malignant brain tumor of gadolinium neutron capture reactions has been preliminary studied. In-vitro C6 37% survival dose (D_<37>) were obtained at 3.55×10^<12>n/cm^2 in 500ppm ^nGd medium, 1.40×10^<12>n/cm^2 in 2,500ppm ^nGd containing medium, and 6.80×10^<12>n/cm^2 in Gd-free medium. The relative killing effect of GdNCT against control study was 1.92 fold for 500ppm ^nGd(+) and 4.86 fold for 2,500ppm Gd(+). The significant survival prolongation of 9L brain tumor rat was observed by intra-venous injection of GdDTPA. Mean survival via GdNCT was 33.5±3.0 days, and that of control rats was 16.4±0.6 days. The optimal Gd concentration was estimated less than 1,000ppm ^<157>Gd for various reasons, since neutron fluence rapidly decrease in the deeply seated tumor due to high absorption of neutron by Gd atoms. The maximum contribution of γ rays on tumor absorbed dose was less than 50%. In a spherical tumor model in diameter of 3cm, approximately 25% of absorbed dose was transferred by γ rays and more that 50% of that by internal conversion electrons. The peri-tumoral dose distribution does not decrease sharply like BNCT. The 10% decrease level was estimated to be 2-3cm from the tumor margin. This blunt dose distribution might be effective to destroy the invading tumor cells in the peri-tumoral lesion manifesting as high density area in T^2-weighted MRI.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348480X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Takagaki, Masao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takagaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Masao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOSMANE, Narayan S.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1099","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-27"}],"displaytype":"detail","filename":"KJ00005223106.pdf","filesize":[{"value":"964.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005223106.pdf","url":"https://aino.repo.nii.ac.jp/record/330/files/KJ00005223106.pdf"},"version_id":"cbf18f91-2f06-44f5-b511-71d89874e041"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"neutron capture therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gadolinium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malignant brain tumors","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gadolinium neutron capture therapy for malignant brain tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gadolinium neutron capture therapy for malignant brain tumors","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["38"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-27"},"publish_date":"2019-03-27","publish_status":"0","recid":"330","relation_version_is_last":true,"title":["Gadolinium neutron capture therapy for malignant brain tumors"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2025-09-11T06:10:31.314633+00:00"}