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The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough
https://aino.repo.nii.ac.jp/records/284
https://aino.repo.nii.ac.jp/records/28404255d42-30ef-4fb1-a2cb-9c2c0474d0f1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004291418.pdf (899.1 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2019-03-27 | |||||
| タイトル | ||||||
| タイトル | The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Montelukast sodium | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Leukotriene receptor antagonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | β_2-adrenoreceptor agonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Atopic cough | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Eosinophilic bronchitis without asthma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11877461 | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P | |||||
| 論文名よみ | ||||||
| タイトル | The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough | |||||
| 著者 |
YAMASAKI, Hidetomo
× YAMASAKI, Hidetomo× YAMASAKI, Keiko× TANAKA, Toshifumi× YAMASAKI, Hideki× OHSAWA, Nakaaki |
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| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Yamasaki Clinic : Aino Institute for Aging Research | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Yamasaki Clinic | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Aino Institute for Aging Research | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Yamasaki Clinic | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Aino Institute for Aging Research | |||||
| 記事種別(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Original Paper | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | There have been extremely a few reports regarding the effectiveness of leukotriene receptor antagonist (LTRA) in the treatment of patients with bronchodilatorunresponsive chronic dry cough (BU-CDC). Methods : Research on 12 patients (4 males, 8 females, 9 with atopic factors; age 41±18 yrs) with BU-CDC was carried out to investigate the effects of a 2-week course of the LTRA montelukast sodium (MT) at a dosage of 10 mg once daily. The patients studied had a cough that had persisted for over 4 weeks, which had already failed to be treated with a 2-week course of the β_2-adrenoreceptor agonist. Their response to MT was clinically judged using a cough score (CS). Results: (1) Of the 12 cases studied, 4 cases (33%) showed a good response, 3 (25%) showed a moderate response, and 5 (42%) showed no response. In the total cases, the rate of effectiveness was 58%, and the improvement rate of CS (i-CS) was 28% (P=0.03). (2) The duration of the cough was negatively correlated with the i-CS (r=-0.48, P=0.08), but there was no correlation between the cough severity and the i-CS. (3) Sub-analysis showed that the longer the cough persisted, the poorer the responsiveness was; the i-CS was, 15% in 6 cases with a cough persisting for over 8 weeks, and 40% in 6 cases with a cough persisting for less than 8 weeks (P=0.10). There were no significant differences between the high CS cases and low CS ones, or between the male cases and female ones. Conclusions : MT is effective not only in the treatment of patients with bronchial asthma and cough variant asthma, but also in the treatment of patients with BU-CDC, mostly corresponding to eosinophilic tracheobronchitis with cough hypersensitivity (Fujimura et al) or eosinophilic bronchitis without asthma (Gibson et al). | |||||
| 書誌情報 |
en : Aino journal 巻 3, 発行日 2004 |
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| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00004291418 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1348480X | |||||
