{"created":"2023-05-15T12:16:38.880887+00:00","id":284,"links":{},"metadata":{"_buckets":{"deposit":"7338a025-e3fd-42c7-a952-4177d20723cc"},"_deposit":{"created_by":4,"id":"284","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"284"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000284","sets":["7:35"]},"author_link":["1016","1018","1019","1015","1017"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"3","bibliographic_titles":[{},{"bibliographic_title":"Aino journal","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"There have been extremely a few reports regarding the effectiveness of leukotriene receptor antagonist (LTRA) in the treatment of patients with bronchodilatorunresponsive chronic dry cough (BU-CDC). Methods : Research on 12 patients (4 males, 8 females, 9 with atopic factors; age 41±18 yrs) with BU-CDC was carried out to investigate the effects of a 2-week course of the LTRA montelukast sodium (MT) at a dosage of 10 mg once daily. The patients studied had a cough that had persisted for over 4 weeks, which had already failed to be treated with a 2-week course of the β_2-adrenoreceptor agonist. Their response to MT was clinically judged using a cough score (CS). Results: (1) Of the 12 cases studied, 4 cases (33%) showed a good response, 3 (25%) showed a moderate response, and 5 (42%) showed no response. In the total cases, the rate of effectiveness was 58%, and the improvement rate of CS (i-CS) was 28% (P=0.03). (2) The duration of the cough was negatively correlated with the i-CS (r=-0.48, P=0.08), but there was no correlation between the cough severity and the i-CS. (3) Sub-analysis showed that the longer the cough persisted, the poorer the responsiveness was; the i-CS was, 15% in 6 cases with a cough persisting for over 8 weeks, and 40% in 6 cases with a cough persisting for less than 8 weeks (P=0.10). There were no significant differences between the high CS cases and low CS ones, or between the male cases and female ones. Conclusions : MT is effective not only in the treatment of patients with bronchial asthma and cough variant asthma, but also in the treatment of patients with BU-CDC, mostly corresponding to eosinophilic tracheobronchitis with cough hypersensitivity (Fujimura et al) or eosinophilic bronchitis without asthma (Gibson et al).","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"14","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00004291418","subitem_description_type":"Other"}]},"item_3_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Paper","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11877461","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348480X","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Yamasaki Clinic : Aino Institute for Aging Research"},{"subitem_text_language":"en","subitem_text_value":"Yamasaki Clinic"},{"subitem_text_language":"en","subitem_text_value":"Aino Institute for Aging Research"},{"subitem_text_language":"en","subitem_text_value":"Yamasaki Clinic"},{"subitem_text_language":"en","subitem_text_value":"Aino Institute for Aging Research"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMASAKI, Hidetomo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMASAKI, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANAKA, Toshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMASAKI, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHSAWA, Nakaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1019","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-27"}],"displaytype":"detail","filename":"KJ00004291418.pdf","filesize":[{"value":"899.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004291418.pdf","url":"https://aino.repo.nii.ac.jp/record/284/files/KJ00004291418.pdf"},"version_id":"4674dc66-3747-478c-b59c-449fbd5d8cbb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Montelukast sodium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Leukotriene receptor antagonist","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β_2-adrenoreceptor agonist","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Atopic cough","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Eosinophilic bronchitis without asthma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["35"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-27"},"publish_date":"2019-03-27","publish_status":"0","recid":"284","relation_version_is_last":true,"title":["The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-05-15T12:30:57.246349+00:00"}