| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-07-13 |
| タイトル |
|
|
タイトル |
The development of artificial organs using decellularization technology |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
biological scaffold, decellularization, drying process, trehalose, recipientʼs serum |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Ishino, Naoaki
Ozaki, Keita
Ueda, Tsubasa
Ishikawa, Yuto
Fujisato, Toshiya
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
As a result of advances in medical technology and legal revisions in relation to organ transplantation, the number of patients who receive organ transplants is increasing annually. However, the number of patients who need an organ transplant still far exceeds
the number of donors, and many patients are forced to wait for their transplant. The development of artificial organs is rapidly advancing together with research into stem cells such as induced pluripotent stem (iPS)cells, and is yielding results. However, there is little prospect of the development of artificial organs that fully imitate complex spatial structures and functions. Decellularized structures, which are fabricated by removing the cellular components that cause rejection from the biological tissue, function as biological scaffolds that have minute structures and mechanical properties derived from living organisms. Decellularized grafts treated using recipient serum have been found to suppress post-transplant immunorejection in comparison with grafts treated with surfactants. With regard to calcification, which is a problem in the case of long-term transplantation, clues to a solution have been obtained through improvements in the decellularization efficiency by means of dessication stress and the tissue preservation
effects of trehalose. Furthermore, dessication stress has also been found to be effective if used together with surfactant treatment methods. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 16,
号 1,
p. 13-18,
ページ数 6,
発行日 2018-03-31
|
| 出版者 |
|
|
出版者 |
AINO UNIVERSITY |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348-480X |
The development of artificial organs using decellularization technology (306.8 kB)
