| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-07-09 |
| タイトル |
|
|
タイトル |
The characteristics and functions of NTAK/Neuregulin-2 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
NTAK/neuregulin-2, EGF family, ErbB, neuron |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 著者 |
Nakano, Norihiko
Kanekiyo, Kenji
Ide, Chizuka
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Neuregulin-2 (NRG2), also known as NTAK (neural- and thymus-derived activator for ErbB kinases), is a member of the epidermal growth factor (EGF) family. The EGF family is involved in cell survival, proliferation, and development, and the ErbB family comprises receptor tyrosine kinases for the EGF family. NTAK/NRG2 is structurally homologous to NRG1, which is a member of the EGF family. NTAK/NRG2 as well as NRG1 binds directly to ErbB3 and ErbB4, and transactivates ErbB1 and ErbB2 via heterodimerization with ErbB3 or ErbB4. NTAK/NRG2 is only expressed in the brain of rat E11.5 embryos, and in the brain and thymus of adult rats in vivo, whereas NRG1 is expressed in the brain, heart, liver, kidneys, spinal cord, ovaries, and skin. NTAK/NRG2 has more than 10 alternatively spliced isoforms. NTAKα and NTAKβ preferentially induce ErbB3 and ErbB4 phosphorylation, respectively, and stimulate the growth of human breast cancer cells. It has been revealed that NTAK/NRG2 functions to control vascular endothelial cells and neurons. NTAKγ and δ inhibit vascular endothelial cell growth and display antiangiogenic activity in the chick embryo chorioallantoic membrane in vivo, whereas NTAKα and β have no activity to angiogenesis. NTAKδ prevents hyper-phosphorylation of the retinoblastoma tumor suppressor protein and causes G1 arrest in vascular endothelial cells. In the nervous system, NTAK/NRG2 is expressed in cultured hippocampal neurons and astrocytes, and NTAK/NRG2 secreted from astrocytes binds to ErbB3 on neurons, and promotes neuronal survival and neurite extension. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 15,
号 1,
p. 81-87,
ページ数 7,
発行日 2017-03-31
|
| 出版者 |
|
|
出版者 |
AINO GAKUIN |
|
言語 |
en |
| ISSN |
|
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348-480X |
11-AIJ1512-11-Norihiko NAKANO (547.6 kB)
