| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-03-27 |
| タイトル |
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|
タイトル |
Are the long-term survival, proliferation, and differentiation of transplanted cells desirable in clinical application for spinal cord injury? |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
spinal cord injury, bone marrow-derived cells, Schwann cell, neural stem/progenitor cell, clinically relevant, safety |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Kanekiyo, Kenji
Nakano, Norihiko
Homma, Tamami
Yamada, Yoshihiro
Tamachi, Masahiro
Ohta, Masayoshi
Suzuki, Yoshihisa
Ide, Chizuka
|
| 抄録(英) |
|
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内容記述タイプ |
Other |
|
内容記述 |
Cell transplantation studies of spinal cord injury have a premise that the transplants should be integrated in the host spinal cord tissue, differentiate into neural cells, and re-establish neural circuits, leading to the improvement of locomotor functions. However, the long-term survival, extensive proliferation, and/or differentiation of transplanted cells are not necessarily desirable clinically, and may, on the contrary, cause serious problems regarding the safety of transplants. The excessive proliferation, migration, and/or differentiation of transplanted cells may deteriorate the histological as well as functional organization of the host spinal cord. The present communication will discuss the feasibility of using three kinds of cell as transplants, including bone marrow-derived cells (BMDCs), Schwann cells, and neural stem/progenitor cells (NSPCs). BMDCs enhance tissue recovery and locomotor improvements; however, they disappear within 2-3 weeks after transplantation from the host spinal cord. This indicates that BMDCs do not serve as scaffolds for the growth of regenerating axons, but promote "endogenous" regenerating capacities of the host spinal cord, probably by secreting some trophic factors. This short-term survival of transplants, although appearing to be a disadvantage, guarantees the safety of cell transplantation. The transplantation of BMDCs is now at the Phase I/II stage of clinical application. Schwann cells have been studied extensively as a transplant material for spinal cord injury. Schwann cells survive long-term, and moderately proliferate and/or migrate in the spinal cord. It can be said that Schwann cells become well integrated in the host spinal cord. Therefore, they are regarded as a safe transplant. NSPCs proliferate, migrate, and differentiate extensively after transplantation in the host spinal cord. It is impossible at present to manipulate or control the proliferation/migration/differentiation of NPSCs to make them properly integrate in the host spinal cord. NSPCs are not considered safe for clinical application. BMDCs and Schwann cells are clinically relevant, while NS/PCs are clinically irrelevant. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 14,
号 1,
p. 69-76,
ページ数 8,
発行日 2016-03-31
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| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348480X |
KJ00010289179.pdf (906.3 kB)
