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Diversity in common epithelial carcinoma, simplicity in sarcoma and leukemia
https://aino.repo.nii.ac.jp/records/396
https://aino.repo.nii.ac.jp/records/396004a8742-0287-410f-8f60-80059544fb55
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010274379.pdf (464.4 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2019-03-27 | |||||||||
| タイトル | ||||||||||
| タイトル | Diversity in common epithelial carcinoma, simplicity in sarcoma and leukemia | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | heterogeneity, common epithelial carcinoma, chromosomal translocation, oncogene | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者 |
Yamada, Yoshihiro
× Yamada, Yoshihiro
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| 抄録(英) | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In some type of leukemia and sarcoma, cancer development mechanism is straightforward ; aberrant activation of single oncogene transforms cells. Such oncogenes are master genes which function upstream of transcriptional cascade. On the other hand, cancer genome analyses clearly show that that of common epithelial cancers such as lung adenocarcinoma is related to accumulations of mutations in "non-master" oncogenes, leading to heterogeneity in aggressiveness and clinical behavior among their patients. Common epithelial carcinomas do not arise from mutations in specific oncogenes but from accelerated growth rate as a result of summation of growth advantage of each driver mutations on a different composition of oncogenes. Because most of human cancers are of epithelial origin, this heterogeneity gives us a challenge both in understanding the molecular mechanism of carcinogenesis and in the treatment of carcinoma. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : Aino journal 巻 12, 号 1, p. 33-38, ページ数 6, 発行日 2014-03-31 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1348480X | |||||||||
