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Up-regulation of VE-cadherin expression by the LMO2 complex promotes vascular remodeling
https://aino.repo.nii.ac.jp/records/387
https://aino.repo.nii.ac.jp/records/38791c4d20c-3587-4cf5-90dc-f2bf48c64e32
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010274119.pdf (532.2 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||
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| 公開日 | 2019-03-27 | |||||||
| タイトル | ||||||||
| タイトル | Up-regulation of VE-cadherin expression by the LMO2 complex promotes vascular remodeling | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | LMO2 complex, angiogenesis, VE-cadherin, Angiopoietin-2 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11877461 | |||||||
| 著者 |
Yamada, Yoshihiro
× Yamada, Yoshihiro
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| 抄録(英) | ||||||||
| 内容記述 | LMO2 and its binding partner TAL1/SCL have essential roles in both hematopoiesis and angiogenesis. Indeed, LMO2 is highly expressed in endothelial cells and hematopoietic stem cells (HSCs) almost exclusively (with exceptions) throughout life. Recently, the first birthplace of HSCs has been identified as hemogenic endothelial cells in the dorsal aorta in mammals. Firstly, the LMO2 complex including TAL1, GATA1/2/3 (i.e., GATA1 or GATA2 or GATA3), and LDB1 play a key role in endothelial to hemogenic endothelial cell transition in the dorsal aorta in producing HSCs. Another role of the LMO2 complex is to remodel the existing vascular system in angiogenesis. In 2007 and 2012, progress was made in dissecting the mechanism of vascular remodeling regulated by the LMO2 complex. Two of the pivotal role players in vascular remodeling, VE-cadherin and angiopoitin-2, were identified to be among the direct targets of the LMO2 transcription factor complex. In this review, the detailed mechanism in vascular remodeling via the LMO2 complex is discussed. | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : AINO JOURNAL 巻 11, 号 1, p. 33-37, ページ数 5, 発行日 2013-03-31 |
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| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1348480X | |||||||
