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The origin of the first blood cell
https://aino.repo.nii.ac.jp/records/368
https://aino.repo.nii.ac.jp/records/3686749de50-e07d-4638-a13e-162e75a98fd3
| 名前 / ファイル | ライセンス | アクション |
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KJ00007510662.pdf (554.4 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||
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| 公開日 | 2019-03-27 | |||||||
| タイトル | ||||||||
| タイトル | The origin of the first blood cell | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | hematopoietic stem cell (HSC), hemangioblast, hemogenic endothelium, dorsal aorta | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11877461 | |||||||
| 著者 |
Yamada, Yoshihiro
× Yamada, Yoshihiro
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| 抄録(英) | ||||||||
| 内容記述 | In mouse development, the first blood cell activity appears in the yolk sac at E7.5(embryonic day 7.5). However,this blood cell activity (primitive hematopoiesis)is restricted to red blood cells (primitive erythrocytes). The pluripotent hematopoietic stem cells which are able to differentiate into all kinds of peripheral blood cell (including lymphocytes)are initially identified in the AGM (aorta-gonad -mesonephros)region at E10.5(definitive hematopoiesis).In vitro studies suggest the presence of hemangioblasts,which can differentiate into both blood and endothelial cells. However, until recently, direct evidence of the presence of these hemangioblasts in vivo was not available, and the precise mechanism of the differentiation of hematopoietic cells from hemangioblasts was totally unknown. Recent progress in this field of study indicates that the first hematopoietic stem cells are generated through the hemogenic endothelium stage and are anatomically derived from the hemogenic endothelium in the dorsal aorta floor of the AGM region. | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : AINO JOURNAL 巻 9, 号 1, p. 27-29, ページ数 3, 発行日 2011-03-31 |
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| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1348480X | |||||||
