| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-03-27 |
| タイトル |
|
|
タイトル |
The effects of adrenal androgens on glucose metabolism of genetically diabetic mice (db/db) -differences between dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S)- |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
diabetes mellitus, DHEA, DHEA-S, db/db mice |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Sakai, Reiko
Furutama, Daisuke
Maeda, Tamaki
Fujimura, Chieko
Tanaka, Toshifumi
Hanafusa, Toshiaki
Koyama, Akio
Ohsawa, Nakaaki
|
| 抄録(英) |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We investigated the effects of DHEA and DHEA-S on glucose metabolism using diabetic mice db/db in vivo. The DHEA-S-treated mice showed more prominent hepatomegaly and a greater decrease of the serum glucose level than DHEA-treated mice. These preliminary data suggest that DHEA-S has a stronger hypoglycemic effect than DHEA, or even that the hypoglycemic effect may be due to DHEA-S, rather than DHEA. The modes of action of DHEA and DHEA-S in diabetic mice should be evaluated from the perspective that these steroids have distinct effects, that can contribute to clarifying the basic pathogenesis of diabetes mellitus. |
|
言語 |
en |
| 書誌情報 |
en : Aino journal
巻 8,
号 1,
p. 35-38,
ページ数 4,
発行日 2010-03-31
|
| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348480X |
KJ00007506819.pdf (466.5 kB)
