| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-03-27 |
| タイトル |
|
|
タイトル |
The effectiveness of treating patients with recurrent cough variant asthma with leukotriene receptor antagonist montelukast sodium : Clinical parameters concerned with therapeutic responsiveness |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Cough variant asthma, Montelukast sodium, Leukotriene receptor antagonist, The elderly, Gender |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11877461 |
| 著者 |
Yamasaki, Hidetomo
Yamasaki, Keiko
Yamasaki, Hideki
Tanaka, Toshifumi
Ohsawa, Nakaaki
|
| 抄録(英) |
|
|
内容記述 |
There have been only a few reports regarding the effectiveness of leukotriene receptor antagonist (LTRA) in the treatment of patients with cough variant asthma (CVA). Methods: The present research in patients (9 males, 17 females; age 59±23 yr) with recurrent CVA was performed to investigate the effectiveness of a 2-week course of the LTRA montelukast sodium (MT) based on clinical use of a cough score (CS). Secondly we performed a sub-analysis of clinical parameters for CS, age, and gender in the condition-matched cases drawn from the total cases. Results: Of the 26 cases studied, the course of MT was effective in 19 cases (rate of responsiveness, 73%; 11 cases, good response; 8 cases, moderate response) and induced no response in 7 cases. MT improved the rate of CS by 37±33%, from 4.7 ±2.2 to 3.2±2.5 points (P<0.001). The improvement rate of CS was significantly related to the CS before treatment (r=-0.47, P=0.02). The therapeutic responsiveness was significantly higher in low score cases than high score cases (P=0.03). Cough severity was assumed to be a parameter of therapeutic responsiveness. Significant differences for therapeutic responsiveness were not observed between non elderly and elderly patients, nor between males and females. Conclusions: MT is sufficiently effective in patients with recurrent CVA. In terms of drug compliance, the understanding of inhaled therapy, and complications in the elderly, elderly cases are considered to be active indications for MT therapy. The present study suggests the recommended concomitance of β_2-agonist or inhaled (or oral) corticosteroids with MT in severe cases at the early stage of treatment. |
|
言語 |
en |
| 書誌情報 |
en : AINO JOURNAL
巻 3,
号 1,
p. 67-72,
ページ数 6,
発行日 2004
|
| ISSN |
|
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1348480X |
KJ00004291417.pdf (645.9 kB)
