{"created":"2023-05-15T12:17:03.999046+00:00","id":749,"links":{},"metadata":{"_buckets":{"deposit":"4c28a434-f152-4a53-8396-7552bc40738e"},"_deposit":{"created_by":8,"id":"749","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"749"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000749","sets":["80:71"]},"author_link":["2672"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"67","bibliographicPageStart":"67","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"藍野大学紀要"},{"bibliographic_title":"Bulletin of Aino University","bibliographic_titleLang":"en"}]}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":" 脊髄損傷モデルラットを用いたこれまでの研究から、神経再生にはニューロン自身のみならず、その周辺のグリア細胞がダイナミックに相互作用することが重要であることがわかってきた。本研究では、種々の栄養因子を含む脳脊髄液産生し、中枢神経系の恒常性維持の役割を担っている脈絡叢上皮細胞に着目した。まず、培養した脈絡叢上皮細胞を脊髄損傷ラットに移植したところ、顕著な神経の再生および行動の回復がみられた。さらに、脈絡叢上皮細胞の培養上清のみを投与した場合でも同様の効果が得られた。これらのことから、脈絡叢上皮細胞が分泌している可溶性因子が神経再生に寄与することがわかった。今後は内在的な脈絡叢上皮細胞による神経再生因子の分泌を促進させるようなメカニズムを解析し、細胞移植を必要としない神経再生治療の新たな方法を開発することを目指す。","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"藍野大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-8745","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"兼清, 健志","creatorNameLang":"ja"},{"creatorName":"カネキヨ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kenji, Kanekiyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"兼清","familyNameLang":"ja"},{"familyName":"カネキヨ","familyNameLang":"ja-Kana"},{"familyName":"Kenji","familyNameLang":"en"}],"givenNames":[{"givenName":"健志","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kanekiyo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2672","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*上皮細胞(移植)","subitem_subject_scheme":"Other"},{"subitem_subject":"*脊髄損傷(実験的,治療)","subitem_subject_scheme":"Other"},{"subitem_subject":"*脈絡叢(移植)","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脈絡叢上皮細胞の脊髄損傷治療への利用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脈絡叢上皮細胞の脊髄損傷治療への利用"}]},"item_type_id":"10002","owner":"8","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-06-30"},"publish_date":"2022-06-30","publish_status":"0","recid":"749","relation_version_is_last":true,"title":["脈絡叢上皮細胞の脊髄損傷治療への利用"],"weko_creator_id":"8","weko_shared_id":8},"updated":"2024-10-11T08:26:29.341153+00:00"}