{"created":"2023-05-15T12:17:03.683000+00:00","id":742,"links":{},"metadata":{"_buckets":{"deposit":"ddbd2ea8-d43b-48d5-8491-0ee1f0e901cf"},"_deposit":{"created_by":8,"id":"742","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"742"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000742","sets":["80:72"]},"author_link":["2662"],"control_number":"742","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"82","bibliographicPageStart":"82","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"藍野大学紀要"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大学院生の突飛な発想から、偶然を見逃さない科学的洞察力(serendipity)によって成果を得た前職場での経験を紹介する。\n成個体脳では神経細胞が新生しないので、脳の再生は不可能とされるが、例外も存在する。例外の1つ、記憶をつかさどる海馬でのニューロン新生について、質的・量的解析をおこなった。飼育ケージに、50cm長のトンネルチューブ（通過センサー付き）を様々な角度でつなげ、その先端には給水器を置いた。給水中には、チミジンアナログのBrdUを溶かしておいた。マウスをトンネル内自由走歩させると、どの角度の場合でも、走歩距離・飲水量（BrdU摂取量） ともに同じであった。一定時間ののち、摂取したBrdUを組織化学的に染色し分裂細胞（新生した細胞）を計数したところ、急な角度（上下距離が大きい）ほど、その値が大きかった。即ち、ニューロン新生には、走行距離ではなく、体重を持ち上げる重力エネルギーが重要であるといえる。\n近年、運動療法の効果は、METS(Metabolic Equivalents)単位に体重を乗じた値に応じるとされ、その機序も体重減少という間接的なものではなく、筋肉が分泌する因子(Myokine)の関与とされている。坂登りエクササイズによって海馬ニューロン数の維持および増加が見込まれる「脳トレ」の効果が示唆された本成果は、ヘルスプロモーションを科学する興味深いものである。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-8745","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 久夫","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisao, Yamada","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Hisao","familyNameLang":"en"}],"givenNames":[{"givenName":"久夫","givenNameLang":"ja"},{"givenName":"ヒサオ","givenNameLang":"ja-Kana"},{"givenName":"Yamada","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2662","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Broxuridine(診断的利用)","subitem_subject_scheme":"Other"},{"subitem_subject":"*海馬","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞計数","subitem_subject_scheme":"Other"},{"subitem_subject":"*細胞分裂","subitem_subject_scheme":"Other"},{"subitem_subject":"*動物の身体調整","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"坂登りエクササイズによって脳トレは可能か","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"坂登りエクササイズによって脳トレは可能か","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"8","path":["72"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-29"},"publish_date":"2022-06-29","publish_status":"0","recid":"742","relation_version_is_last":true,"title":["坂登りエクササイズによって脳トレは可能か"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-10-11T09:47:31.862837+00:00"}