{"created":"2023-05-15T12:17:03.554454+00:00","id":740,"links":{},"metadata":{"_buckets":{"deposit":"60393d06-4933-4937-94bc-87f6c21dbaf9"},"_deposit":{"created_by":8,"id":"740","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"740"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000740","sets":["80:72"]},"author_link":["2689"],"control_number":"740","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"81","bibliographicPageStart":"81","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"藍野大学紀要"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ｉ型コラーゲンは細胞が接着する足場となるため再生医療や幹細胞研究において注目されている。これまでに、低接着性Ｉ型コラーゲン（Low Adhesive Scaffold Collagen, LASCol）上で培養すると、線維芽細胞をはじめとする数種類の細胞は凝集塊を形成し増殖能が低下することがわかっている。そこで、神経組織におけるLASColの足場機能の解析を行った。\n　まず、LASCol上での神経系細胞の挙動をin vitroで解析したところ、アストロサイトは接着する細胞が少なく増殖能の低下がみられた。一方、神経細胞はLASCol上で神経突起が著しく伸長し、細胞の生存能が亢進した。\n　次に、脊髄損傷モデルラットにLASColゲルを損傷部に埋入し、in vivoでの神経再生効果を検討した。免疫組織化学的解析の結果、LASColを埋入したラットの脊髄損傷部に再生神経の伸長が認められた。また、BBBスコアによる行動学的解析の結果、LASCol埋入群はコントロール群に比べて有意な回復がみられた。\n　これらのことから、LASColは脊髄損傷治療に有望な足場材料となることがわかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-8745","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中野, 法彦","creatorNameLang":"ja"},{"creatorName":"ナカノ, ノリヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Norihiko, Nakano","creatorNameLang":"en"}],"familyNames":[{"familyName":"中野","familyNameLang":"ja"},{"familyName":"ナカノ","familyNameLang":"ja-Kana"},{"familyName":"Norihiko","familyNameLang":"en"}],"givenNames":[{"givenName":"法彦","givenNameLang":"ja"},{"givenName":"ノリヒコ","givenNameLang":"ja-Kana"},{"givenName":"Nakano","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2689","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*脊髄損傷(実験的,治療)","subitem_subject_scheme":"Other"},{"subitem_subject":"*接着性","subitem_subject_scheme":"Other"},{"subitem_subject":"*Collagen Type I","subitem_subject_scheme":"Other"},{"subitem_subject":"組織足場","subitem_subject_scheme":"Other"},{"subitem_subject":"*脊髄再生","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"細胞低接着性コラーゲンを足場とした脊髄損傷に対する神経再生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞低接着性コラーゲンを足場とした脊髄損傷に対する神経再生","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"8","path":["72"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-29"},"publish_date":"2022-06-29","publish_status":"0","recid":"740","relation_version_is_last":true,"title":["細胞低接着性コラーゲンを足場とした脊髄損傷に対する神経再生"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-10-11T09:10:20.942578+00:00"}