{"created":"2023-05-15T12:16:41.957873+00:00","id":347,"links":{},"metadata":{"_buckets":{"deposit":"e1a41ea0-8a12-4382-81ad-f2082fc253c1"},"_deposit":{"created_by":4,"id":"347","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"347"},"status":"published"},"_oai":{"id":"oai:aino.repo.nii.ac.jp:00000347","sets":["7:39"]},"author_link":["1131","1132","1130","1134","1129","1135","1133"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"7","bibliographic_titles":[{},{"bibliographic_title":"Aino journal","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The morphological changes were examined in the dorsal funiculus after cryoinjury to the spinal cord at Th10 in the rat. Cryoinjury was performed by contacting a liquid nitrogen-frozen metal rod with the dorsal surface of the spinal cord. The frozen spinal cord was thawed spontaneously. This freeze-thawing treatment was repeated three times. The histological changes were examined by light and electron microscopy from 2 to 60 days after cryoinjury. The present study focused on the electron microscopic findings of the degenerative and regenerative changes of nerve fibers and glial cells following injury. In typical Waller degeneration, myelin sheaths of degenerated axons were separated from oligodendrocytes, and phagocytozed by macrophages. Within the lesion, while glial cells including oligodendrocytes were degraded, some axons were rescued from the damage, surviving as demyelinated axons after the degradation of associated oligodendrocytes. Such demyelinated axons were later remyelinated by oligodendrocytes or Schwann cells. This might be a major factor contributing to the locomotive recovery of the animal. Growth cones were formed even after a long period following cryoinjury at the proximal stump of the injured nerves. This suggests that nerve fibers have a strong ability to regenerate in the spinal cord dorsal funiculus. A cavity was usually formed in the epicenter to rostral part of the lesion. Cavity formation is a critical barrier to spinal cord regeneration. The main strategies for spinal cord regeneration might be to rescue and restore neural tissues from degeneration, and prevent cavity formation by providing a sufficient blood supply to ensure tissue survival and axonal outgrowth. ","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"8","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00007502819","subitem_description_type":"Other"}]},"item_3_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original article ","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11877461","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348480X","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Nursing and Rehabilitation, Aino University"},{"subitem_text_language":"en","subitem_text_value":"Department of Plastic and Reconstructive Surgery, Tazuke Medical Research Institute, Kitano Hospital"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regeneration and Rehabilitation, Aino University"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Degenerative and of regenerative changes in the dorsal funiculus of the cryoinjured spinal cord of rats -electron microscopic study-"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAI, Yoshiyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1129","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKANO, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ENDO, Katsuaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1131","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NODA, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1132","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUZUKI, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IDE, Chizuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1135","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-27"}],"displaytype":"detail","filename":"KJ00007502819.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00007502819.pdf","url":"https://aino.repo.nii.ac.jp/record/347/files/KJ00007502819.pdf"},"version_id":"530faa84-9f48-4a01-a4d7-d1ada74ba977"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spinal cord cryoinjury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electon microscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oligodendrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Schwann cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myelination","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Degenerative and of regenerative changes in the dorsal funiculus of the cryoinjured spinal cord of rats -electron microscopic study-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Degenerative and of regenerative changes in the dorsal funiculus of the cryoinjured spinal cord of rats -electron microscopic 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