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The role of a transcription factor LYL1 in leukemogenesis
https://aino.repo.nii.ac.jp/records/343
https://aino.repo.nii.ac.jp/records/34346cf8b05-7cfd-48b4-8c88-681d5e4f96de
| 名前 / ファイル | ライセンス | アクション |
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KJ00007501759.pdf (346.8 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2019-03-27 | |||||||||
| タイトル | ||||||||||
| タイトル | The role of a transcription factor LYL1 in leukemogenesis | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | LYL1, lymphoma, basic helix-loop-helix transcription factor/ E2A, transgenick mice, two-hybrid assay | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者 |
Yamada, Yoshihiro
× Yamada, Yoshihiro
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| 抄録(英) | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | A number of transcription factors were revealed in the study of chromosomal translocation associated with T cell acute lymphoblastic leukemia. LYL1 is one of the examples of such transcription factors. LYL1 is a member of the class II basic helix-loop-helix transcription factors and aberrantly expressed in a fraction of human T cell acute lymphoblastic leukemia. The mechanism of leukemogenesis by LYL1 has been studied in transgenic mouse ubiquitously overexpressing LYL1 using a construct expressing full-length cDNA driven by a human elongation factor 1α promoter. 30% of these transgenic mice developed malignant lymphoma with an average latent period of 352 days. Lymphomas developed are both B and T cell lymphomas. LYL1 forms a heterodimer with another basic helix-loop-helix protein E2A. Overexpressed LYL1 inhibits the E2A/HEB heterodimer formation, thus inactivates the physiological function of E2A, which might be the essential step to leukemogenesis. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : AINO JOURNAL 巻 7, 号 1, p. 9-12, ページ数 4, 発行日 2009-03-31 |
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| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1348480X | |||||||||
