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The Role of an LMO2/TAL1 (SCL)/GATA complex in definitive hematopoiesis
https://aino.repo.nii.ac.jp/records/326
https://aino.repo.nii.ac.jp/records/3266aa71ddc-700a-413c-b77b-8bea6f50498f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005223102.pdf (3.7 MB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2019-03-27 | |||||||||
| タイトル | ||||||||||
| タイトル | The Role of an LMO2/TAL1 (SCL)/GATA complex in definitive hematopoiesis | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | transcription factor complex, hematopoiesis, LIM domain, protein-protein interaction, chromosomal translocation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者 |
Yamada, Yoshihiro
× Yamada, Yoshihiro
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| 抄録(英) | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The basic helix-loop-helix transcription factor Tall (Scl), the LIM-finger protein Lmo 2, and the GATA-finger proteins Gata1/2/3 have important roles in hematopoiesis. Genetic disruption of Tall (Scl) and Lmo2 individually results in defective yolk sac erythropoiesis and definitive hematopoiesis. These transcription factors physically interact with each other to form an Lmo2/Tall/Gata1/2/3 transcription factor complex. In order to know whether these transcription factors form a complex to play critical roles in hematopoiesis, mutant Lmo2s were made to specifically disrupt the interaction between Lmo2 and Gata1/2/3 by introducing a mutation in the LIM 2 domain of Lmo2. Overexpression of these mutant Lmo2s in mice severely impaired fetal liver hematopoiesis and thymus development, indicating its role as a master complex for the development of the entire hematopoietic system. In this complex, Lmo2 functions as an adapter molecule and cell-autonomously determines the fate of each blood cell to either erythroid or lymphoid cell by recruiting Gata1/2/3 at different stage of hematopoietic differentiation. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : AINO JOURNAL 巻 6, 号 1, p. 3-18, ページ数 16, 発行日 2008-03-31 |
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| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1348480X | |||||||||
