2026-03-13T02:44:21Z https://aino.repo.nii.ac.jp/oai

oai:aino.repo.nii.ac.jp:00000789 2025-09-11T04:12:07Z 7:74

Effects of trophic factors on the treatment of spinal cord injury in rats Ide, Chizuka Nakano, Norihiko Kanekiyo, Kenji Yamada, Yoshihiro Homma, Tamami Tamachi, Masahiro Abe, Seiya Miyamoto, Chimi Tsukagoshi, Chihiro spinal cord injury cell transplantation trophic factor intrinsic ability to regenerate clinical safety We studied the effects of the transplantation of bone marrow stromal cells (BMSCs) on spinal cord injury (SCI) in rats. BMSC transplantation promoted distinct locomotor improvements of rats with SCI. However, contrary to expectations, BMSCs disappeared within 2-3 weeks after transplantation. They were not integrated into the host spinal cord tissue. There was no finding indicating that BMSCs supported the outgrowth of regenerating axons as a scaffold in the spinal cord lesion. This finding indicated that BMSCs, instead of physically supporting axonal outgrowth, secreted some trophic factors/molecules effective for tissue repair, including the growth of regenerating axons, in SCI. The same finding was obtained in the study using choroid plexus epithelial cells (CPECs) as a transplant for the treatment of SCI. These findings are important, as they show that the spinal cord has its own ability to regenerate. This concept is different from the current standpoint of cell transplantation therapy, whereby transplanted cells should be integrated into the host tissue to support the outgrowth of regenerating axons. This generally accepted concept of cell transplantation appears reasonable, but suggests a serious problem. Neural stem cells (NSCs) were integrated into the host tissue, and differentiated into neurons, astrocytes and oligodendrocytes. Neurons that differentiate from NSCs extend numerous axons to distant locations. The problem is that there is no method available to control such unusual axonal extension, differentiation, and migration. There is no way to integrate safely into the host spinal cord tissue. This means that neural stem cell transplantation is too dangerous to be used for clinical application. Regeneration studies have no significance if they have no avenue for clinical application. In this mini-review, we outline our previous studies, and survey other studies focusing on the use of trophic substances for the treatment of SCI. departmental bulletin paper AINO UNIVERSITY 2018-03-31 application/pdf AINO JOURNAL 1 16 89 97 1348-480X https://aino.repo.nii.ac.jp/record/789/files/Effects of trophic factors on the treatment of spinal cord injury in rats.pdf https://aino.repo.nii.ac.jp/records/789 eng