2026-03-13T02:17:54Z https://aino.repo.nii.ac.jp/oai

oai:aino.repo.nii.ac.jp:00000320 2025-09-11T06:11:07Z 7:37

Interstitial pneumonia and de-novo onset of asthma induced by leuprorelin acetate for prostate cancer Yamasaki, Hidetomo Yamasaki Hidetomo Nakajima, Hideto Nakajima Hideto Tanaka, Toshifumi Tanaka Toshifumi Ohsawa, Nakaaki Ohsawa Nakaaki leuprorelin acetate interstitial pneumonia chemokine receptor Th 1/Th 2 balance bronchial asthma prostate cancer We describe herein the first report of side effects induced by leuprorelin acetate (LA) administration. A 70-year-old man, with idiopathic pulmonary fibrosis (IPF), vasospastic angina, diabetes mellitus type 2, and arteriosclerosis obliterans was suffering from prostate cancer. LA administration (drug-) induced interstitial pneumonia based on IPF and the de-novo onset of bronchial asthma, both of which are thought to be Th 2-related diseases. Using 3-color flow cytometry, we analyzed the chemokine receptors CD4+CXCR3+/CD3+ and CD4+CCR4+/CD3+, and found that the CXCR3/CCR4 ratio changed in the Th 2 pattern. It is important to be careful with LA administration, especially for underlying Th 2-related diseases, and clinicians should fully understand the possibilities of LA-inducing de-novo Th 1/Th 2-driven autoimmune diseases. 2006 eng departmental bulletin paper https://aino.repo.nii.ac.jp/records/320 1348480X AINO JOURNAL 5 1 4 73 76 https://aino.repo.nii.ac.jp/record/320/files/KJ00005223091.pdf application/pdf 554.6 kB 2019-03-27